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Mostafizur Rahman, Md.
- Evaluation of Antioxidant, Antino Potentialities of Methanolic Extract of Memecylon umbellatum
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Authors
Affiliations
1 Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217, BD
1 Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217, BD
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 2 (2012), Pagination: 84-88Abstract
The methanolic extract of leaves of Memecylon umbellatum (Melastomtaceae) was evaluated for in vitro antioxidant activity by determination of hydrogen peroxide scavenging activity, total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test and in vivo antinociceptive effect in acetic acid induced writhing model in Swiss albino mice. The plant extract was also subjected for brine shrimp lethality bio-assay to evaluate its cytotoxic property. The results revealed the presence of pronounced antioxidant property as compared with ascorbic acid used as standard and a dose-dependent (250 and 500 mg/kg) analgesic effect. Investigation also showed that it has strong lelthality (LC50 1.178 μg/ml) against brine shrimp nauplii, Vincristine Sulphate was used as positive control. The antioxidant, antinociceptive and cytotoxic properties observed seem to be in good accordance with the traditional uses of Memecylon umbellatum.Keywords
Memecylon umbellatum, Melastomataceae, Antioxidant, Antinociceptive, Swiss Albino Mice, Cytotoxicity, Vincristine Sulphate.- Free Radical Scavenging Activity and Cytotoxic Potential of Crude Extractives of Murraya paniculata (L.) Bark
Abstract Views :151 |
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Authors
Affiliations
1 Department of Pharmacy, Stamford University, 51, Siddeswari Road, Dhaka-1217, BD
2 Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University, Dhaka-1217, BD
1 Department of Pharmacy, Stamford University, 51, Siddeswari Road, Dhaka-1217, BD
2 Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University, Dhaka-1217, BD
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 1 (2012), Pagination: 18-22Abstract
The present study was accomplished to evaluate the crude methanolic extract of Murraya paniculata (L.) bark for in-vitro free radical scavenging activity by determination of hydrogen peroxide scavenging activity, total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test. Besides, the petroleum ether, chloroform and methanol extractives of bark were screened for brine shrimp lethality bio-assay to evaluate their cytotoxic potential. The results revealed the presence of pronounced antioxidant property as compared with ascorbic acid used as standard, as well as all the extractives of the plant showed strong lethality (LC50: 0.84±0.19 μg/ml, LC50: 1.17±0.03 μg/ml, LC50: 1.31±0.16 μg/ml, respectively) against brine shrimp nauplii, as compared with positive control, Vincristine Sulphate (LC50: 0.33±0.12 μg/ml).Keywords
Murraya paniculata (L.), Rutaceae, Free Radical, Antioxidant, Brine Shrimp, Cytotoxicity.- Integrated Development Strategies:Key Components of Strategic Approaches
Abstract Views :96 |
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Authors
Affiliations
1 Department of Architecture, Shahjalal University of Science and Technology, Sylhet-3114, BD
2 Department of Civil and Environmental Engineering, Shahjalal University of Science and Technology, Sylhet-3114, BD
1 Department of Architecture, Shahjalal University of Science and Technology, Sylhet-3114, BD
2 Department of Civil and Environmental Engineering, Shahjalal University of Science and Technology, Sylhet-3114, BD